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Viruses immune evasion and host adaptation Viral infection induces diverse immune responses in the host that work coordinately to eliminate the virus and clear the infection. To establish infection, viruses have evolved numerous immune evasion mechanisms that allow them to replicate and spread in the host despite the antiviral immune responses. Understanding the basis of the dynamic interaction between the immune system and viruses is therefore essential for developing novel therapeutic approaches for viral infection. In our lab, we aim to shed light on the complex interaction between viruses and the immune system. We use advanced single-genome sequencing techniques and other virological and immunological methods to monitor immune responses to viral infection and to identify the mechanisms used by viruses to escape these antiviral responses. We focus on respiratory viruses such as influenza virus and SARS-COV-2

 

The clonality of the antiviral immune response We are interested in mapping the TCR landscape in HIV-1 infected individuals. The major barrier for HIV-1 cure is the presence of CD4+ T cells that harbor a latent HIV-1 provirus. By analyzing the unique TCRs that are expresses on latently infected cells, we are developing novel tolls to dissect the HIV-1 latent reservoir. Our long-term goal is to provide in-depth analysis of the factors that regulate HIV-1 latency. 

 

Antibody-mediated immune responses By using viral infection as a model, we are aiming on understating the basis of antibody-mediated immune activation and viral escape from antibody recognition. We are using this information to develop novel antibodies which will provide sustained viral suppression.